Sudipta Roy1*, Tapan Kumar Mandal2, Uttam Datta2
*1Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Hooghly
2Department of Veterinary Pharmacology and Toxicology
2Department of Gynaecocology and Obstetrics
West Bengal University of Animal and Fishery Sciences, Belgachia, Kolkata-37
OBJECTIVE: India is suffering from Overpopulation over the past few decades. Considering the side effects of reversible control of fertility using hormonal preparations, bioactive compounds from marine ecosystem showing medicinal potentials have been discovered. The present study was undertaken to explore the efficacy of bio-active molecules isolated from marine snail Telescopium telescopium against fertility in female rats through intra muscular route of administration post coitally.
METHODS: Telescopium telescopium, family Potamididae, was collected from estuaries of Bay of Bengal near Sagar Island (22º19?N; 80º03?E) in West Bengal. The spermatheca/ ovotestis gland was dissected and processed at 4ºC. It was named Telescopium spermatheca extract (TSE) and stored at -20ºC. Thirty female Wistar albino rats were divided into 5 groups followed by treatment with Phosphate Buffer Saline, Marketed formulation and 24, 48 and 80 mg/kg of TSE respectively. Glucose, Cholesterol, Total Protein, Progesterone and haemogram were studied from blood collected at 0, 7th and 14th day. The data was analyzed statistically by ANOVA using Graph Pad Prism Software.
RESULTS: Effective results were obtained with 80 mg/kg body weight of TSE, where number of animals conceived, number and weight of the litters decreased significantly. Percentage of Heamoglobin, PCV and WBC increased significantly. The level of protein and glucose decreased whereas, cholesterol and progesterone level increased significantly with the advancement of the days of pregnancy.
CONCLUSION:The results of the present study provides a new approach that outlines a basic idea in the development of a suitable, non-toxic and economic contraceptive agent from marine source for the first time as an initial step.
Key Words: Contraceptive, Overpopulation, Post coital, Telescopium telescopium.